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Clinical diagnosis and management of amyotrophic lateral sclerosis.
J Neurol Neurosurg Psychiatry doi:10.1136/jnnp-2011-300188
The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study
- Julie Phukan1, Marwa Elamin1, Peter Bede1, Norah Jordan2, Laura Gallagher2,
- Susan Byrne1, Catherine Lynch1, Niall Pender2, Orla Hardiman1,3
+ Author Affiliations
1Trinity College Institute of Neuroscience, Dublin, Ireland
2Department of Neuropsychology, Beaumont Hospital, Dublin, Ireland
3Department of Neurology, Beaumont Hospital Dublin, Dublin, Ireland
Correspondence to Dr Marwa Elamin, Trinity College Institute of Neuroscience, Dublin, Ireland;
Neurology. 2011 Apr 5;76(14):1263-9.
Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia.
J Neurol. 2011 Mar;258(3):359-65. Epub 2010 Nov 17.
Management of respiratory symptoms in ALS.
Source: HRB Clinician Scientist, Trinity College and Beaumont Hospital, Dublin, Ireland. orla@hardiman.net
Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives.
The complexity of care in amyotrophic lateral sclerosis.
National ALS Clinic, Beaumont Hospital ALS Clinic, Dublin, Ireland.
PMID: 21294666 [PubMed - as supplied by publisher]
Proposed criteria for familial amyotrophic lateral sclerosis.
TCIN, Trinity College, Dublin, Ireland.
McLaughlin RL, Phukan J, McCormack W, Lynch DS, Greenway M, Cronin S, Saunders
J, Slowik A, Tomik B, Andersen PM, Bradley DG, Jakeman P, Hardiman O. Angiogenin
levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis. PLoS
One. 2010 Nov 10;5(11):e15402. PubMed PMID: 21085671; PubMed Central PMCID:
PMC2978104.
Hardiman O. Management of respiratory symptoms in ALS. J Neurol. 2010 Nov 17.
[Epub ahead of print] PubMed PMID: 21082322.
ALSUntangled Group. ALSUntangled No. 7: Investigating hyperimmune goat serum
(Aimspro) for ALS. Amyotroph Lateral Scler. 2010 Dec;11(6):571-3. PubMed PMID:
21077806.
Byrne S, Walsh C, Lynch C, Bede P, Elamin M, Kenna K, McLaughlin R, Hardiman
O. Rate of familial amyotrophic lateral sclerosis: a systematic review and
meta-analysis. J Neurol Neurosurg Psychiatry. 2010 Nov 3. [Epub ahead of print]
PubMed PMID: 21047878.
ALSUntangled Group. ALSUntangled No. 6: Investigating Marty Murray's method.
Amyotroph Lateral Scler. 2010 Oct;11(5):494-6. PubMed PMID: 20839919.
Tong P, Prendergast JG, Lohan AJ, Farrington SM, Cronin S, Friel N, Bradley
DG, Hardiman O, Evans A, Wilson JF, Loftus B. Sequencing and analysis of an Irish
human genome. Genome Biol. 2010;11(9):R91. Epub 2010 Sep 7. PubMed PMID:
20822512; PubMed Central PMCID: PMC2965383.
Shatunov A, Mok K, Newhouse S, Weale ME, Smith B, Vance C, Johnson L, Veldink
JH, van Es MA, van den Berg LH, Robberecht W, Van Damme P, Hardiman O, Farmer AE,
Lewis CM, Butler AW, Abel O, Andersen PM, Fogh I, Silani V, Chiò A, Traynor BJ,
Melki J, Meininger V, Landers JE, McGuffin P, Glass JD, Pall H, Leigh PN, Hardy
J, Brown RH Jr, Powell JF, Orrell RW, Morrison KE, Shaw PJ, Shaw CE, Al-Chalabi
A. Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven
other countries: a genome-wide association study. Lancet Neurol. 2010
Oct;9(10):986-94. PubMed PMID: 20801717.
Beghi E, Chiò A, Couratier P, Esteban J, Hardiman O, Logroscino G, Millul A,
Mitchell D, Preux PM, Pupillo E, Stevic Z, Swingler R, Traynor BJ, Van Den Berg
LH, Veldink JH, Zoccolella S. The epidemiology and treatment of ALS: Focus on the
heterogeneity of the disease and critical appraisal of therapeutic trials.
Amyotroph Lateral Scler. 2010 Aug 11. [Epub ahead of print] PubMed PMID:
20698807.
Blauw HM, Al-Chalabi A, Andersen PM, van Vught PW, Diekstra FP, van Es MA,
Saris CG, Groen EJ, van Rheenen W, Koppers M, Van't Slot R, Strengman E, Estrada
K, Rivadeneira F, Hofman A, Uitterlinden AG, Kiemeney LA, Vermeulen SH, Birve A,
Waibel S, Meyer T, Cronin S, McLaughlin RL, Hardiman O, Sapp PC, Tobin MD, Wain
LV, Tomik B, Slowik A, Lemmens R, Rujescu D, Schulte C, Gasser T, Brown RH Jr,
Landers JE, Robberecht W, Ludolph AC, Ophoff RA, Veldink JH, van den Berg LH. A
large genome scan for rare CNVs in amyotrophic lateral sclerosis. Hum Mol Genet.
2010 Oct 15;19(20):4091-9. Epub 2010 Aug 4. PubMed PMID: 20685689.
ALSUntangled Group. ALSUntangled No. 5: investigating the Stowe/Morales ALS
Protocol. Amyotroph Lateral Scler. 2010 Aug;11(4):414-6. PubMed PMID: 20564794.
Donaghy C, Clarke J, Patterson C, Kee F, Hardiman O, Patterson V. The
epidemiology of motor neuron disease in Northern Ireland using capture-recapture
methodology. Amyotroph Lateral Scler. 2010 Aug;11(4):374-8. PubMed PMID:
20550486.
ALSUntangled Group. ALSUntangled update 4: investigating the XCell-Center.
Amyotroph Lateral Scler. 2010 May 3;11(3):337-8. PubMed PMID: 20443222.
Byrne S, Hardiman O. Familial aggregation in amyotrophic lateral sclerosis.
Ann Neurol. 2010 Apr;67(4):554. PubMed PMID: 20437599.
Beghi E, Logroscino G, Chiò A, Hardiman O, Millul A, Mitchell D, Swingler R,
Traynor BJ. Amyotrophic lateral sclerosis, physical exercise, trauma and sports:
results of a population-based pilot case-control study. Amyotroph Lateral Scler.
2010 May 3;11(3):289-92. PubMed PMID: 20433412.
O'Doherty LJ, Hickey A, Hardiman O. Measuring life quality, physical function
and psychological well-being in neurological illness. Amyotroph Lateral Scler.
2010 Oct;11(5):461-8. PubMed PMID: 20192883.
ALSUntangled Group. ALSUntangled Update 3: Investigating stem cell
transplants at the Hospital San Jose Tecnologico de Monterrey. Amyotroph Lateral
Scler. 2010;11(1-2):248-9. PubMed PMID: 20184522.
Yeo L, Lynch C, Hardiman O. Validating population-based registers for ALS:
how accurate is death certification? J Neurol. 2010 Aug;257(8):1235-9. Epub 2010
Feb 12. PubMed PMID: 20151145.
Donaghy C, Pinnock R, Abrahams S, Cardwell C, Hardiman O, Patterson V,
McGivern RC, Gibson JM. Slow saccades in bulbar-onset motor neurone disease. J
Neurol. 2010 Jul;257(7):1134-40. Epub 2010 Feb 10. PubMed PMID: 20146069.
ALSUntangled Update 2: investigating the Hickey Wellness Center.
ALSUntangled Group.
Amyotroph Lateral Scler. 2009 Oct-Dec;10(5-6):490-1. No abstract available. PMID: 19922147 [PubMed - in process]
Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis.
Van Es MA, Van Vught PW, Veldink JH, Andersen PM, Birve A, Lemmens R, Cronin S, Van Der Kooi AJ, De Visser M, Schelhaas HJ, Hardiman O, Ragoussis I, Lambrechts D, Robberecht W, Wokke JH, Ophoff RA, Van Den Berg LH.
Amyotroph Lateral Scler. 2009 Oct-Dec;10(5-6):441-7.PMID: 19922138 [PubMed - in process]
Prognostic factors in ALS: A critical review.
Chiò A, Logroscino G, Hardiman O, Swingler R, Mitchell D, Beghi E, Traynor BG; Eurals Consortium.
Amyotroph Lateral Scler. 2009 Oct-Dec;10(5-6):310-23.PMID: 19922118 [PubMed - in process]
Ten years of the ALS journal.
Hardiman O.
Amyotroph Lateral Scler. 2009 Oct-Dec;10(5-6):257. No abstract available. PMID: 19922111 [PubMed - in process]
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
van Es MA, Veldink JH, Saris CG, Blauw HM, van Vught PW, Birve A, Lemmens R, Schelhaas HJ, Groen EJ, Huisman MH, van der Kooi AJ, de Visser M, Dahlberg C, Estrada K, Rivadeneira F, Hofman A, Zwarts MJ, van Doormaal PT, Rujescu D, Strengman E, Giegling I, Muglia P, Tomik B, Slowik A, Uitterlinden AG, Hendrich C, Waibel S, Meyer T, Ludolph AC, Glass JD, Purcell S, Cichon S, Nöthen MM, Wichmann HE, Schreiber S, Vermeulen SH, Kiemeney LA, Wokke JH, Cronin S, McLaughlin RL, Hardiman O, Fumoto K, Pasterkamp RJ, Meininger V, Melki J, Leigh PN, Shaw CE, Landers JE, Al-Chalabi A, Brown RH Jr, Robberecht W, Andersen PM, Ophoff RA, van den Berg LH.
Nat Genet. 2009 Oct;41(10):1083-7. Epub 2009 Sep 6.PMID: 19734901 [PubMed - indexed for MEDLINE]
Incidence of amyotrophic lateral sclerosis in Europe.
Logroscino G, Traynor BJ, Hardiman O, Chiò A, Mitchell D, Swingler RJ, Millul A, Benn E, Beghi E.
J Neurol Neurosurg Psychiatry. 2009 Aug 25. [Epub ahead of print]PMID: 19710046 [PubMed - as supplied by publisher]
ALSUntangled update 1: investigating a bug (Lyme Disease) and a drug (Iplex) on behalf of people with ALS.
ALSUntangled Group.
Amyotroph Lateral Scler. 2009 Aug;10(4):248-50. No abstract available. PMID: 19701824 [PubMed - indexed for MEDLINE]
Huntington's disease presenting as amyotrophic lateral sclerosis.
Phukan J, Ali E, Pender NP, Molloy F, Hennessy M, Walsh RJ, Hardiman O.
Amyotroph Lateral Scler. 2009 Jun 15:1-3. [Epub ahead of print]PMID: 19530012 [PubMed - as supplied by publisher]
ALSUntangled (ALSU): a scientific approach to off-label treatment options for people with ALS using tweets and twitters.
Bedlack R, Hardiman O.
Amyotroph Lateral Scler. 2009 Jun;10(3):129-30. No abstract available. PMID: 19455452 [PubMed - indexed for MEDLINE]
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
Landers JE, Melki J, Meininger V, Glass JD, van den Berg LH, van Es MA, Sapp PC, van Vught PW, McKenna-Yasek DM, Blauw HM, Cho TJ, Polak M, Shi L, Wills AM, Broom WJ, Ticozzi N, Silani V, Ozoguz A, Rodriguez-Leyva I, Veldink JH, Ivinson AJ, Saris CG, Hosler BA, Barnes-Nessa A, Couture N, Wokke JH, Kwiatkowski TJ Jr, Ophoff RA, Cronin S, Hardiman O, Diekstra FP, Leigh PN, Shaw CE, Simpson CL, Hansen VK, Powell JF, Corcia P, Salachas F, Heath S, Galan P, Georges F, Horvitz HR, Lathrop M, Purcell S, Al-Chalabi A, Brown RH Jr.
Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9004-9. Epub 2009 May 18.PMID: 19451621 [PubMed - indexed for MEDLINE]
148th ENMC international workshop on the scientific contributions of the EURALS consortium on amyotrophic lateral sclerosis.
Beghi E, Pupillo E, Zoccolella S; European Amyotrophic Lateral Sclerosis Consortium (EURALS).
Neuromuscul Disord. 2009 May;19(5):379-81. Epub 2009 Apr 3. No abstract available. PMID: 19345585 [PubMed - indexed for MEDLINE]
Ocular fixation instabilities in motor neurone disease. A marker of frontal lobe dysfunction?
Donaghy C, Pinnock R, Abrahams S, Cardwell C, Hardiman O, Patterson V, McGivern RC, Gibson JM.
J Neurol. 2009 Mar;256(3):420-6. Epub 2009 Mar 18.PMID: 19306041 [PubMed - indexed for MEDLINE]
The management of amyotrophic lateral sclerosis.
Phukan J, Hardiman O.
J Neurol. 2009 Feb;256(2):176-86. Epub 2009 Feb 17. Review.PMID: 19224316 [PubMed - indexed for MEDLINE]
Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis.
Van Es MA, Van Vught PW, Veldink JH, Andersen PM, Birve A, Lemmens R, Cronin S, Van Der Kooi AJ, Visser MD, Schelhaas HJ, Hardiman O, Ragoussis I, Lambrechts D, Robberecht W, Wokke JH, Ophoff RA, Van Den Berg LH.
Amyotroph Lateral Scler. 2009 Feb 19:1-7. [Epub ahead of print]PMID: 19177248 [PubMed - as supplied by publisher
Screening for replication of genome-wide SNP associations in sporadic ALS.
Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O.
Eur J Hum Genet. 2009 Feb;17(2):213-8. Epub 2008 Nov 5.PMID: 18987618 [PubMed - indexed for MEDLINE]
Aggregation of neurodegenerative disease in ALS kindreds.
Fallis BA, Hardiman O.
Amyotroph Lateral Scler. 2009 Apr;10(2):95-8.PMID: 18608094 [PubMed - indexed for MEDLINE]
Kieran D, Sebastia J, Greenway MJ, King MA, Connaughton D, Concannon CG, Fenner B, Hardiman O, Prehn JH
Control of motoneuron survival by angiogenin.
J Neurosci. 2008 Dec 24;28(52):14056-61.PMID: 19109488 [PubMed - indexed for MEDLINE]
Original Article
S Cronin, MJ Greenway, PM Andersen, O Hardiman.
Screening of hypoxia-inducible genes in sporadic ALS.
Amyotrophic Lateral Sclerosis 2008; IFirst DOI 10.1080/17482960802160297
Original Article
S Cronin, S Berger, J Ding, JC Schymick, N Washecka, DG Hernandez, MJ Greenway, DG Bradley, BJ Traynor, O Hardiman
A genome-wide association study of sporadic ALS in a homogenous Irish population
Hum Mol Genet 2008; 17:768-774
Original Article
Brooks A. Fallis, Orla Hardiman
Aggregation of neurodegenerative disease in ALS kindreds
Amyotrophic Lateral Sclerosis 18 June 2008. DOI: 10.1080/17482960802209664
Original Article
Donaghy C, Dick A, Hardiman O, Patterson V.
Timeliness of diagnosis in motor neurone disease: a population-based study.
Ulster Med J. 2008 Jan;77(1):18-21. PMID: 18269112 [PubMed - indexed for MEDLINE]
Review Paper
Del Barco DG, Berlanga J, Penton E, Hardiman O, Montero E.
Boosting controlled autoimmunity: a new therapeutic target for CNS disorders.
Expert Rev Neurother. 2008 May;8(5):819-25. Review. PMID: 18457538 [PubMed - indexed for MEDLINE]
Original Article
Meisler MH, Russ C, Montgomery KT, Greenway M, Ennis S, Hardiman O, Figlewicz DA, Quenneville NR, Conibear E, Brown RH Jr.
Evaluation of the Golgi trafficking protein VPS54 (wobbler) as a candidate for ALS.
Amyotroph Lateral Scler. 2008 Jun;9(3):141-8. PMID: 18574757 [PubMed - indexed for MEDLINE]
Original Article
Broom WJ, Greenway M, Sadri-Vakili G, Russ C, Auwarter KE, Glajch KE, DupreN, Swingler RJ, Purcell S, Hayward C, Sapp PC, McKenna-Yasek D, Valdmanis PN,Bouchard JP, Meininger V, Hosler BA, Glass JD, Polack M, Rouleau GA, Cha JH, Hardiman O, Brown RH Jr.
50bp deletion in the promoter for superoxide dismutase 1 (SOD1) reduces SOD1 expression in vitro and may correlate with increased age of onset of sporadic amyotrophic lateral sclerosis.
Amyotroph Lateral Scler. 2008 Aug;9(4):229-37. PMID: 18608091 [PubMed - indexed for MEDLINE
Original Article
Cronin S, Blauw HM, Veldink JH, van Es MA, Ophoff RA, Bradley DG, van den
Berg LH, Hardiman O.
Analysis of genome-wide copy number variation in Irish and Dutch ALS populations.
Hum Mol Genet. 2008 Nov 1;17(21):3392-8. Epub 2008 Aug 7. PMID: 18689356 [PubMed - indexed for MEDLINE]
Kieran D, Sebastia J, Greenway MJ, King MA, Connaughton D, Concannon CG,Fenner B, Hardiman O, Prehn JH.
Control of motoneuron survival by angiogenin.
J Neurosci. 2008 Dec 24;28(52):14056-61. PMID: 19109488 [PubMed - in process]
Chio A, Logroscino G, Hardiman O, Swingler R, Mitchell D, Beghi E, Traynor BG.
Prognostic factors in ALS: A critical review.
Amyotroph Lateral Scler. 2008 Dec 5:1-14. [Epub ahead of print] PMID: 19061053 [PubMed - as supplied by publisher]
Original Article
Phukan J, Pender N, Hardiman O.
Cognitive impairment in Amyotrophic lateral sclerosis.
Lancet Neurology.
2007;6: 994-1003 17945153.
Original Article
Hosback S , Hardiman O, Nolan CM, Doyle M , Gorman G, Lynch C, O’Toole O, Jakeman P
Circulating Insulin-Like Growth Factors and Related Binding Proteins are Selectively Altered in Amyotrophic Lateral Sclerosis and Multiple Sclerosis.
Growth Hormone Research. 2007 Aug 11; 17(6): 472-479 YGHIR655.
Original Article
Cronin S, Hardiman O, Traynor BJ
Ethnic variation in the incidence of ALS: a systematic review.
Neurology. 2007 Mar 27;68(13):1002-7. PMID: 17389304 [PubMed - in process]
Original Article
Cronin S, Greenway MJ. , Prehn JH., Hardiman O.
Paraoxonase promoter and intronic variants modify risk of sporadic ALS,
J Neurol Neurosurg Psychology 2007 Sept; 78 (9): 984-6.
Original Article
Longroscino G, Traynor BJ, Hardiman O, Mitchell D, Swingler R, Beghi E
Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues
J Neurol Neurosurg Psychiatry (in press)
Original Article
Foley G, O' Mahony P, Hardiman O .
Perceptions of quality of life in people with ALS: effects of coping and health care.
Amyotrophic Lateral Scler 2007 Jun;8(3):164-9
Original Article
Schymick J, Yang Y, Andersen P, Vonsattel J, Greenway M, Momeni P, Elder J, Chio A, Restagno G,
Robberecht W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli R, Hutton M, Gass J, Cannon A,
Rademakers R, Singleton A, Hardiman O, Rothstein J, Hardy J, Traynor B.
Progranulin mutations and ALS or ALS-FTD phenotypes.
J Neurol Neurosurg Psychiatry. 2007 Mar 19; [Epub ahead of print] PMID: 17371905
Original Article
Meldrum D, Cahalane E, Conroy R, Fitzgerald D, Hardiman O.
Maximum voluntary isometric contraction: reference values and clinical application.
Amyotroph Lateral Scler. 2007 Feb;8(1):47-55. PMID: 17364436
Original Article
Hardiman O, Greenway M
The complex genetics of amyotrophic lateral sclerosis.
Lancet Neurol. 2007 Apr;6(4):291-2.. PMID: 17362828
Original Article
O'Toole O, Traynor BJ., Brennan p., Sheehan C., Frost E., Corr B., Hardiman O.
Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004.
Neurol. Neurosurg. Psychiatry, Jul 2007; doi:10.1136/jnnp.2007.117788
Original Article
Momeni P, Schymick J, Jain S, Cookson MR, Cairns NJ, Greggio E, Greenway MJ, Berger S, Pickering-Brown S, Chio A, Fung HC, Holtzman DM, Huey ED, Wassermann EM, Adamson J, Hutton ML, Rogaeva E, St George-Hyslop P, Rothstein JD, Hardiman O, Grafman J, Singleton A, Hardy J, Traynor BJ.
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
BMC Neurol. 2006 Dec 13;6:44. PMID: 17166276
Original Article
Cronin S, Greenway MJ, Ennis S, Kieran D, Green A, Prehn JH, Hardiman O.
Elevated serum angiogenin levels in ALS.
Neurology. 2006 Nov 28;67(10):1833-6. PMID: 17130418
Original Article
Beghi E, Logroscino G, Chio A, Hardiman O, Mitchell D, Swingler R, Traynor BJ; on behalf of the EURALS Consortium.
The epidemiology of ALS and the role of population-based registries.
Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1150-7. Epub 2006 Sep 29.
Original Article
Greenway MJ, Andersen PM, , Russ C, Ennis S, Cashman S, Donaghy C, Patterson V, Swingler R, Morrison KE, Prehn JP, Green A, Acharya KR, ,. Brown RH, Hardiman O.
Loss-of-function ANG mutations segregate with familial and ‘sporadic’ amyotrophic lateral sclerosis
Nature Genetics. 2006 Apr;38(4):411-3. Epub 2006 Feb 26. PMID: 16501576 [PubMed - in process].
Original Article
Parkinson N, Ince PG, Smith MO, Highley R, Skibinski G, Andersen PM, Morrison KE,
Pall HS, Hardiman O, Collinge J, Shaw PJ, Fisher EM.
ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B).
Neurology. 2006 Jun 28; [Epub ahead of print]
Original Article
O’Sullivan PJ, Gorman GM, Hardiman O, Farrell MJ, Logan PM
Sonographically guided percutaneous muscle biopsy in diagnosis of neuromuscular disease: a useful alternative to open surgical biopsy.
J Ultrasound Med. 2006 Jan;25(1):1-6
Original Article
Goodall EF, Greenway MJ, van Marion I, Carroll CB, Hardiman O, Morrison KE.
Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS.
Neurology. 2005 Sep 27;65(6):934-7.
Original Article
Andersen P, Borasio G, Dengler R, Hardiman O, Kollewe K Leigh PN;. Pradat;V. Silani V TomikB
EFNS task force on management of amyotrophic lateral sclerosis: guidelines for diagnosing and clinical care of patients and relatives.
Eur J Neurol. 2005 Dec;12(12):921-38.
Original Article
Tatiana Zaldivar, Yusef Montejo, AM Acevedo, R Guerra, J Vargas, N Garfalo, R Alvarez, M Alvarez, Hardiman O.
Evidence of Reduced Frequency of SMA1 in a Cuban.
Neurology 2005 Aug 23;65(4):636-8.
Original Article
Morgan RK, McNally S, Alexander M, Conroy R, Hardiman O, Costello RW.
Use of Sniff Nasal Inspiratory Force to Predict Survival in Amyotrophic Lateral Sclerosis.
Am J Respir Crit Care Med. 2005 Feb 1;171(3):269-74.
Original Article
Greenway M, Alexander M, Ennis S, Green A, Hardiman O
A new candidate region on chromosome 14 in ALS.
Neurology 2004 Nov 23;63(10):1936-8.
Original Article
Hardiman O, Hickey A, O’Doherty L
Quality of Life and Functional Decline in ALS and Other Motor Neurone Diseases 2004
5, 230-234
Original Article
Kidney D, Alexander M, Corr B, O'Toole O, Hardiman O.
Oropharyngeal dysphagia in amyotrophic lateral sclerosis: neurological and dysphagia specific rating scales.
Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Sep;5(3):150-3
Original Article
Traynor BJ, Alexander M, Corr B., Frost E, Mahon L, Hardiman O
Effect of evidence-based clinical practice on ALS survival in Ireland: A population-based study, 1996 – 2001
J Neurol Neurosurgery Psychiatry 2003;74;1258-61
Original Article
Hardiman O, Corr B, Frost E, Gibbons P, Mahon L, Traynor BJ.
Access to health services in Ireland for people with multiple sclerosis and motor neurone disease.
Irish Medical Journal 2003;96:8:200-203
Original Article
Ryan A, Nor AM, Costigan D, Foley-Nolan D, El-Rafie A, Farrell MA, Hardiman O.
Polymyositis masquerading as motor neuron disease.
Arch Neurol. 2003 Jul;60(7):1001-3.
Original Article
Galvin, C.D., Hardiman O, and Nolan, C.M
An autocrine role for the IGF signalling system in differentiation of primary myoblasts.
Mol Cell Endocrinol. 2003 Feb 28;200(1-2):19-29.
Original Article
Traynor BJ, Alexander M, Conroy R, Corr B., Frost E, Mahon L, Hardiman O
An outcome study of riluzole in amyotrophic lateral sclerosis--a population-based study in Ireland, 1996-2000.
J Neurol 2003 Apr;250(4):473-9.
Original Article
Meldrum D, Atkins N, Cahalane A, Barrett A Hardiman O.
Maximum Voluntary Isometric Contraction (MVIC) - Investigation of Intra-Rater Reliability and Learning Effect.
ALS and Other Motor Neurone Disorders 2003 Mar;4(1):36-44.
Original Article
Hardiman O, Traynor, BJ, Corr B, Frost E.
Models of Care in Motor Neurone Disease: Setting Standards.
ALS and Other Motor Neurone Diseases 2002 3: 4; 182-185
Original Article
Alexander MD, Traynor BJ, Miller N, Corr B, Frost E, McQuaid S, Brett FM, Green A, Hardiman O.
"True" sporadic ALS associated with a novel SOD-1 mutation.
Ann Neurol. 2002 Nov;52(5):680-3.
Original Article
Thornton FJ, Fotheringham T, Alexander M, Hardiman O, McGrath FP, Lee MJ.
Amyotrophic lateral sclerosis: enteral nutrition provision - endoscopic or radiologic gastrostomy?
Radiology. 2002 Sep;224(3):713-7
Original Article
Clarke S, Hickey A, O’Boyle C, Hardiman O.
Assessing individual quality of life in ALS Assessing individual quality of life in amyotrophic lateral sclerosis.
Quality of Life Research 2001:10:149-159
Original Article
Borasio GD, Shaw PJ, Hardiman O, Ludolph A, Sales Luis ML,
Silani V for the European ALS Study Group Standards of palliative care for patients with amyotrophic lateral sclerosis: results of a European survey.
ALS and other Motor Neurone Diseases 2001 2:3 159-165 PMID: 11771773
Original Article
Traynor BJ, Codd M, Corr B, Forde C, Frost E, Hardiman O
Clinical Features of ALS using the El Escorial and Airlie House diagnostic criteria: A population-based study.
Arch Neurol 2000 57: 1171-16
Original Article
Hardiman O.
Pitfalls in the diagnosis of Motor Neurone Disease.
Hospital Medicine 2000 61:11;767-71
Original Article
Traynor BJ, Codd MB, Corr B, Forde C, Frost E, Hardiman O
Amyotrophic lateral sclerosis mimic syndromes: a population-based study.
Arch Neurol 2000 Jan;57(1):109-13
Original Article
Hardiman O.
Symptomatic Management of nutrition and ventilation in ALS.
J Neurol 1999 247:245-251
Original Article
Traynor BJ, Codd M, Corr B, Forde C, Hardiman O.
Incidence and prevalence of ALS in Ireland 1995-1997. A prospective population based study.
Neurology, 1999, Feb;52(3):504-9.
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